Neural underpinnings of comorbid posttraumatic stress and excessive alcohol use: Opposing effects on loss-related mediofrontal theta in combat veterans.

A shared neural mechanism appears to underlie co-occurring posttraumatic stress and hazardous alcohol use and highlights the potential for interventions targeting mediofrontal theta signaling to improve the functioning of individuals experiencing these conditions. Future clinical interventions that target mediofrontal theta might modulate exaggerated negative salience processing and effectively reduce trauma-related psychopathology and the draw of alcohol consumption.