Positive effect of leptin substitution on mood and behaviour in patients with congenital leptin deficiency.

Julia von SchnurbeinMiriam RemyStephanie BrandtJaida ManzoorKatja KohlsdorfSaqib MahmoodJohannes HebebrandMartin Wabitsch

Published in: Pediatric obesity (2023)

Metreleptin substitution improved indices of physical activity and psychological wellbeing in patients with CLD. This suggests that reduced leptin concentrations might be in part responsible for emotional and behavioural changes seen during starvation.

Keyphrases

physical activity
sleep quality
bipolar disorder
body mass index
replacement therapy