The role of the C. albicans transcriptional repressor NRG1 during filamentation and disseminated candidiasis is strain-dependent.

function can reduce filamentation, hypha-specific gene expression such as the toxin candidalysin, and virulence in some strains. Our data emphasize that the functions of seemingly fundamental and well-conserved transcriptional regulators such as Nrg1 are contextual with respect to both environment and genetic background.