D-type cyclins regulate DNA mismatch repair in the G1 and S phases of the cell cycle, maintaining genome stability.

Gergely RonaBearach Miwatani-MinterQingyue ZhangHailey V GoldbergMarc A KerzhnermanJesse B HowardDaniele SimoneschiEthan LaneJohn W HobbsElizabeth SassaniAndrew A WangSarah KeeganDaniel J LavertyCortt G PiettLorinc S PongorMiranda Li XuJoshua AndradeAnish ThomasPiotr SicinskiManor AskenaziBeatrix UeberheideDavid FenyöZachary D NagelMichele Pagano

Published in: bioRxiv : the preprint server for biology (2024)

To maintain genome stability, D-type cyclins limit mismatch repair (MMR) in G1, whereas their degradation is necessary for proper MMR function in S phase.

Keyphrases

cell cycle
cell proliferation
genome wide
single molecule
gene expression
dna methylation