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Cystine Induced-mTORC2 Activation through Promoting Sin1 Phosphorylation to Suppress Cancer Cell Ferroptosis.

GuoYan WangLei ChenSenLin QinYiNing ZhengChao XiaJunHu YaoPing WangLu Deng
Published in: Molecular nutrition & food research (2022)
These results indicate that cystine-induced activation of the p38-Sin1-mTORC2-AKT pathway suppresses ferroptosis.
Keyphrases
  • high glucose
  • cell death
  • diabetic rats
  • signaling pathway
  • drug induced
  • cell proliferation
  • endothelial cells
  • oxidative stress
  • protein kinase