Reversal of insulin resistance in people with obesity by lifestyle-induced weight loss does not impact the proportion of circulating 12α-hydroxylated bile acids.

Anna PalmiottiKirsten A BerkMartijn KoehorstMilaine V HovinghAlle T PrangerMartijn van FaassenJan Freark de BoerEline S van der ValkElisabeth F C van RossumMonique T MulderFolkert Kuipers

Published in: Diabetes, obesity & metabolism (2024)

Lifestyle-induced weight loss did improve glycaemic control but did not affect BA concentrations. Improvements in insulin sensitivity were not associated with changes in BA parameters in people with obesity, with or without T2D.

Keyphrases

weight loss
bariatric surgery
roux en y gastric bypass
gastric bypass
high glucose
metabolic syndrome
diabetic rats
type diabetes
weight gain
glycemic control
insulin resistance
cardiovascular disease
obese patients
adipose tissue
body mass index