LR12 Promotes Liver Repair by Improving the Resolution of Inflammation and Liver Regeneration in Mice with Thioacetamide- (TAA-) Induced Acute Liver Failure.

Yongjuan WangXiaoli XieHongqun LiuHuimin LiuHui-Qing Jiang

Published in: Mediators of inflammation (2021)

LR12 could improve the resolution of inflammation and liver regeneration in mice with TAA-induced ALF by promoting the secretion of CCL20 from macrophages and activating the p38 MAPK pathway. Therefore, LR12 could be an attractive therapeutic target for the treatment of ALF.

Keyphrases

liver failure
stem cells
oxidative stress
high fat diet induced
single molecule
signaling pathway
diabetic rats
drug induced
liver injury
adipose tissue
metabolic syndrome
endothelial cells
combination therapy