The Tumor-Associated Calcium Signal Transducer 2 (TACSTD2) oncogene is upregulated in pre-cystic epithelial cells revealing a new target for polycystic kidney disease.
Abigail O SmithWilliam Tyler FrantzKenley M PrevalYvonne J K EdwardsYvonne J K EdwardsJulie A JonassenGregory J PazourPublished in: medRxiv : the preprint server for health sciences (2023)
The oncogene, tumor-associated calcium signal transducer 2 (Tacstd2) mRNA increased in abundance shortly after Pkd2 loss and may be a driver of cyst initiation in polycystic kidney disease.