Subclinical Left Ventricular Dysfunction is Influenced by Genotype Severity in Patients with Cystic Fibrosis.
Michael PallinDominic Thomas KeatingDavid M KayeTom KotsimbosJohn W WilsonPublished in: Clinical medicine insights. Circulatory, respiratory and pulmonary medicine (2018)
This study is the first to show that in CF, severity of genotype (functional classification) is associated with cardiac impairment. Patients with severe CF genotype and cardiac dysfunction should be identified to evaluate cardiac response to gene-modifying treatments prior to consideration for lung transplantation.
Keyphrases
- cystic fibrosis
- left ventricular
- pseudomonas aeruginosa
- oxidative stress
- heart failure
- machine learning
- acute myocardial infarction
- hypertrophic cardiomyopathy
- lung function
- cardiac resynchronization therapy
- deep learning
- aortic stenosis
- left atrial
- copy number
- coronary artery disease
- air pollution
- acute coronary syndrome
- drug induced
- catheter ablation