Leptin Attenuates Cardiac Hypertrophy in Patients With Generalized Lipodystrophy.

My-Le NguyenVandana SachdevThomas R BurklowWen LiMegan StartzellSungyoung AuhRebecca J Brown

Published in: The Journal of clinical endocrinology and metabolism (2021)

Metreleptin attenuated cardiac hypertrophy and improved septal e' velocity in GLD, which may be mediated by reduced lipotoxicity and glucose toxicity. The applicability of these findings to leptin-sufficient populations remains to be determined.

Keyphrases

oxidative stress
blood glucose
blood flow
hypertrophic cardiomyopathy
heart failure
type diabetes
skeletal muscle
left ventricular
insulin resistance