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Genome-wide association analysis identifies a GLUL haplotype for familial hepatitis B virus-related hepatocellular carcinoma.

You-Yu LinMing-Whei YuShi-Ming LinShou-Dong LeeChih-Ling ChenDing-Shinn ChenPei-Jer Chen
Published in: Cancer (2017)
To the authors' knowledge, the current study is the first genome-wide association study to identify genetic factors for familial HBV-related HCC. The results identified 2 large effect susceptible haplotypes located at GLUL and SLC13A2/FOXN1. The current study findings also suggest different genetic susceptibility between familial and sporadic HBV-related HCC. Cancer 2017;123:3966-76. © 2017 American Cancer Society.
Keyphrases
  • hepatitis b virus
  • liver failure
  • genome wide
  • early onset
  • papillary thyroid
  • genome wide association study
  • healthcare
  • squamous cell
  • late onset
  • gene expression
  • dna methylation
  • copy number
  • childhood cancer
  • young adults