Radiation necrosis in renal cell carcinoma brain metastases treated with checkpoint inhibitors and radiosurgery: An international multicenter study.
Eric J LehrerJason GurewitzKenneth BernsteinDev PatelDouglas KondziolkaAjay NiranjanZhishuo WeiL Dade LunsfordTimothy D MalouffHenry Ruiz-GarciaSamir PatelPhillip A BonneyLindsay HwangCheng YuGabriel ZadaDavid MathieuClaire TrudelRahul N PrasadJoshua D PalmerBrianna M JonesSonam SharmaKareem R FakhouryChad G RusthovenChristopher P DeibertPiero PicozziAndrea FranziniLuca AttuatiCheng-Chia LeeHuai-Che YangManmeet S AhluwaliaJason P SheehanDaniel M TrifilettiPublished in: Cancer (2022)
Symptomatic RN occurs in a minority of patients with RCC brain metastases treated with ICI/SRS. The majority of events were grade 1 to 3 and were managed medically. Concurrent ICI/SRS does not appear to increase this risk. Attempts to improve dose conformality (reduce V12) may be the most successful mitigation strategy in single-fraction SRS.