Rapid one-pot radiosynthesis of [carbonyl-11C]formamides from primary amines and [11C]CO2.

This study demonstrates the feasibility of 11C-formylation of primary amines with the primary synthon [11C]CO2. The reactivity is proportional to the nucleophilicity of the precursor amine. This novel method can be used for the production of biomolecules containing a radiolabelled formyl group.