Single-cell peripheral immunoprofiling of lewy body and Parkinson's disease in a multi-site cohort.

Thanaphong PhongpreechaKavita MathiBrenna CholertonEddie J FoxNatalia SigalCamilo EspinosaMomsen ReinckePhilip ChungLing-Jen HwangChandresh R GajeraEloise BersonAmalia PernaFeng XieChi-Hung ShuDebapriya HazraDivya ChannappaJeffrey E DunnLucas B KippKathleen L PostonKathleen S MontineHolden T MaeckerNima AghaeepourThomas J Montine

Published in: Molecular neurodegeneration (2024)

Quantification of PBMC immune response from multisite research participants yielded a unique pattern for LBD compared to HC, multiple related neurodegenerative diseases, and autoimmune diseases thereby highlighting potential biomarkers and mechanisms of disease.

Keyphrases

immune response
single cell
parkinson disease
high throughput
toll like receptor
deep brain stimulation