Model-Based Meta-Analysis Supporting the Combination of Acetaminophen and Topical Diclofenac in Acute Pain: A Therapy for Mild-to-Moderate Osteoarthritis Pain?
Vidhu SethiLi QinEugène CoxIñaki F TrocónizOscar Della PasquaPublished in: Pain and therapy (2024)
Our results indicate greater pain reduction and opioid-sparing efficacy for the AtopD combination versus acetaminophen monotherapy. Given the similar pain pathways and mechanisms of action of the two drugs in acute and mild-to-moderate OA pain, comparable beneficial effects from the combination therapy may be anticipated following extrapolation to chronic OA pain. Prospective RCTs and real-world studies in OA pain are needed to confirm the differences in the efficacy of the combination treatment observed in our study.
Keyphrases
- spinal cord injury
- neuropathic pain
- chronic pain
- pain management
- combination therapy
- systematic review
- liver failure
- open label
- hepatitis b virus
- clinical trial
- aortic dissection
- postoperative pain
- smoking cessation
- respiratory failure
- acute respiratory distress syndrome
- meta analyses
- double blind
- case control
- mechanical ventilation