Glial injury in neurotoxicity after pediatric CD19-directed chimeric antigen receptor T cell therapy.

Juliane GustOlivia C FinneyDaniel LiHannah M BrakkeRoxana M HicksRobert B FutrellDanielle N GambleStephanie D Rawlings-RheaHedieh K KhalatbariGisele E IshakVirginia E DuncanRobert F HevnerMichael C JensenJulie R ParkRebecca A Gardner

Published in: Annals of neurology (2019)

Our data are most consistent with ICANS as a syndrome of systemic inflammation, which affects the brain through compromise of the neurovascular unit and astrocyte injury. ANN NEUROL 2019.

Keyphrases

neuropathic pain
big data
case report
stem cells
machine learning
young adults
spinal cord
neural network
multiple sclerosis
nk cells