The Liver Cirrhosis Network Cohort Study: Cirrhosis Definition, Study Population, and Endpoints.
Elliot B TapperDavid S GoldbergNeehar D ParikhNorah A TerraultNicole WelchSuzanne SharptonBilal HameedMandana KhaliliAndrew A StolzElizabeth C VernaRobert S BrownArun J SanyalLisa B Van WagnerDaniela P LadnerCynthia A MoylanAnna Mae DiehlPatricia D JonesStephen CaldwellSrinivasan DasarathyDouglas A SimonettoVijay H ShahJasmohan Singh Bajajnull nullPublished in: The American journal of gastroenterology (2024)
The LCN Cohort Study design will inform the natural history of cirrhosis in contemporary patients with compensated cirrhosis. The LCN Definitions and Measures Committee developed criteria for the definition of cirrhosis to standardize entry into this multi-center cohort study and standardized criteria for liver-related outcome measures. This effort has produced definitions intended to be both sensitive and specific as well as easily operationalized by study staff such that outcomes critical to the LCN cohort are identified and reported in an accurate and generalizable fashion.
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