Dysregulated NUB1 and neddylation enhances rheumatoid arthritis fibroblast-like synoviocyte inflammatory responses.
Sho SendoCamilla R L MachadoDavid L BoyleRobert J BenschopNarayanan B PerumalEunice ChoiWei WangGary S FiresteinPublished in: Arthritis & rheumatology (Hoboken, N.J.) (2024)
CUL1 neddylation and NUB1 induction is dysregulated in RA, which increases FLS activation. Inhibition of neddylation is an effective therapy in an animal model of arthritis. These data suggest that neddylation system contributes to the pathogenesis of RA and that regulation of neddylation could be a novel therapeutic approach.