Pharmaceutical Reactivation of Attenuated Apoptotic Pathways Leads to Elimination of Osimertinib Drug-Tolerant Cells.
Matthew J MartinNicolas Floc'hMatthias PfeiferSteven CriscioneOona DelpuechSladjana GagricaYi YaoUltan McDermottPaul D SmithPublished in: Cancer research communications (2022)
These studies uncover strategies to use targeted agents that activate apoptosis in non-small cell lung cancer cells that survive initial EGFR TKI treatment.
Keyphrases
- cell cycle arrest
- cell death
- small cell lung cancer
- epidermal growth factor receptor
- tyrosine kinase
- induced apoptosis
- advanced non small cell lung cancer
- endoplasmic reticulum stress
- oxidative stress
- single cell
- pi k akt
- cell therapy
- case control
- signaling pathway
- anti inflammatory
- bone marrow
- emergency department