Predictors and Pathophysiology of Axial Postural Abnormalities in Parkinsonism: A Scoping Review.
Carlo Alberto ArtusiChristian GeroinJorik NonnekesCamila Catherine AquinoDivyani GargMarian L DaleDarbe SchlosserYijie LaiMohammad Al-WardatMehri SalariRobin WolkeValery Tsinda LabouGabriele ImbalzanoSerena CamozziMarcello MerelloBastiaan R BloemTamine CapatoRuth DjaldettiKaren DohertyAlfonso FasanoHouyam TibarLeonardo LopianoNils G MargrafCaroline MoreauYoshikazu UgawaRoongroj BhidayasiriMichele Tinazzinull nullPublished in: Movement disorders clinical practice (2023)
The recognition of clinical predictors and pathophysiology of axial postural abnormalities in parkinsonism is far from being elucidated due to literature bias, encompassing different inclusion criteria and measurement tools and heterogeneity of patient samples. Most studies identified advanced disease stage and higher burden of motor symptoms as possible clinical predictors. Pathophysiology data point toward many different (possibly non-mutually exclusive) mechanisms, including dystonia, rigidity, proprioceptive and vestibular impairment, and higher cognitive deficits.