Model-Informed Support of Dose Selection for Prophylactic Treatment with Dalcinonacog Alfa in Adult and Paediatric Hemophilia B Patients.

Alan FarajNatacha Le MoanEduard GorinaGrant E BlouseTom KnudsenUlrika S H Simonsson

Published in: Advances in therapy (2023)

This study supported the adult dose selection for DalcA in the presence of sparse data and enabled first-in-paediatric dose selection to achieve FIX levels that reduce risk of spontaneous bleeds.

Keyphrases

end stage renal disease
intensive care unit
emergency department
chronic kidney disease
newly diagnosed
ejection fraction
peritoneal dialysis
prognostic factors
electronic health record
machine learning
big data
artificial intelligence
patient reported outcomes
data analysis