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Hi-C profiling of cancer spheroids identifies 3D-growth-specific chromatin interactions in breast cancer endocrine resistance.

Jingwei LiKun FangLavanya ChoppavarapuKe YangYini YangJunbai WangRuifeng CaoIsmail JatoiVictor X Jin
Published in: Clinical epigenetics (2021)
Hence, our work has provided significant insights into our understanding of 3D-growth-specific chromatin architecture in tamoxifen-resistant breast cancer. Our analyses suggest that the strengthened looping-mediated Hippo relevant pathways may contribute to endocrine therapy resistance in breast cancer patients.
Keyphrases
  • genome wide
  • dna damage
  • gene expression
  • transcription factor
  • papillary thyroid
  • childhood cancer
  • stem cells
  • single cell
  • squamous cell
  • positive breast cancer
  • young adults
  • bone marrow
  • mesenchymal stem cells