Hi-C profiling of cancer spheroids identifies 3D-growth-specific chromatin interactions in breast cancer endocrine resistance.
Jingwei LiKun FangLavanya ChoppavarapuKe YangYini YangJunbai WangRuifeng CaoIsmail JatoiVictor X JinPublished in: Clinical epigenetics (2021)
Hence, our work has provided significant insights into our understanding of 3D-growth-specific chromatin architecture in tamoxifen-resistant breast cancer. Our analyses suggest that the strengthened looping-mediated Hippo relevant pathways may contribute to endocrine therapy resistance in breast cancer patients.