Heterogeneity and excitability of BRAF V600E-induced tumors is determined by Akt/mTOR-signaling state and Trp53-loss.

Silvia Cases-CunilleraKaren M J van LooJulika PitschAnne QuatraccioniSugirthan SivalingamPaolo SalomoniValeri BorgerDirk DietrichSusanne SchochAlbert J Becker

Published in: Neuro-oncology (2021)

mTOR-signaling and Trp53-loss critically determine the biological diversity and electrical activity of BRAF V600E-induced tumors.

Keyphrases

cell proliferation
high glucose
diabetic rats
drug induced
signaling pathway
single cell
oxidative stress