mRNA vaccines against SARS-CoV-2 induce divergent antigen-specific T-cell responses in patients with lung cancer.

No-Joon SongKarthik B ChakravarthyHyeongseon JeonChelsea BolyardKelsi ReynoldsKevin P WellerSarah ReisingerYi WangAnqi LiSizun JiangQin MaDan H BarouchMark P RubinsteinPeter G ShieldsEugene M OltzDongjun Chung Zihai Li

Published in: Journal for immunotherapy of cancer (2024)

We conclude that patients with lung cancer on immunotherapy show a substantial qualitative deviation from non-cancer subjects in their T-cell response to mRNA vaccines, highlighting the need for heightened protective measures for patients with cancer to minimize the risk of breakthrough infection with the Omicron and other future variants.

Keyphrases

sars cov
papillary thyroid
binding protein
squamous cell
copy number
current status
respiratory syndrome coronavirus
systematic review
childhood cancer