Primary Aldosteronism: Spatial Multiomics Mapping of Genotype-Dependent Heterogeneity and Tumor Expansion of Aldosterone-Producing Adenomas.

Siyuan GongNa SunLucie S MeyerMartina TettiChristina Koupourtidou Stefan Krebs Giacomo Masserdotti Helmut BlumWilliam E RaineyMartin ReinckeAxel WalchTracy Ann Williams

Published in: Hypertension (Dallas, Tex. : 1979) (2023)

Our findings provide insight into intra- and intertumoral transcriptional heterogeneity and support a role for prooxidant versus antioxidant systems in APA pathogenesis highlighting genotype-dependent capacities for tumor expansion.

Keyphrases

single cell
high resolution
oxidative stress
gene expression
transcription factor
mass spectrometry