Pharmacokinetics and Pharmacodynamics of Systemic Corticosteroids in Autoimmune and Inflammatory Diseases: A Review of Current Evidence.
Julia E MöhlmannSolaiman EzzafzafiCaroline A LindemansMarc H A JansenStefan NierkensAlwin D R HuitemaMatthijs van LuinPublished in: Clinical pharmacokinetics (2024)
There is insufficient evidence to draw firm conclusions on the potential associations between PK and clinical outcome of systemic corticosteroid treatment in autoimmune and inflammatory diseases. This is remarkable given the many decades that steroid drugs have been used in clinical care. Prospective research is recommended with robust and well-defined cohorts to fully quantify the PK/PD associations of corticosteroids.