Mutant U2AF1-Induced Mis-Splicing of mRNA Translation Genes Confers Resistance to Chemotherapy in Acute Myeloid Leukemia.
Peng JinXiaoling WangQiqi JinYi ZhangJie ShenGe JiangHong-Ming ZhuMing ZhaoDan WangZeyi LiYan ZhouWenzhu LiWei ZhangYabin LiuSiyang WangWen JinYuncan CaoGuangying ShengFangyi DongShishuang WuXiaoyang LiZhen JinMengke HeXiaxin LiuLuo-Nan ChenYunxiang ZhangKankan WangJunmin LiPublished in: Cancer research (2024)
U2AF1 mutations induce the integrated stress response by disrupting splicing of mRNA translation genes that improves AML cell fitness to enable resistance to chemotherapy, which can be targeted to improve AML treatment.
Keyphrases
- acute myeloid leukemia
- atrial fibrillation
- genome wide
- locally advanced
- bioinformatics analysis
- genome wide identification
- single cell
- physical activity
- binding protein
- allogeneic hematopoietic stem cell transplantation
- body composition
- cell therapy
- diabetic rats
- cancer therapy
- dna methylation
- genome wide analysis
- radiation therapy
- chemotherapy induced
- rectal cancer
- gene expression
- drug induced
- combination therapy
- wild type