The addition of chloroquine and bevacizumab to standard radiochemotherapy for recurrent glioblastoma multiforme.

Hanno M WitteArmin RieckeKonrad SteinestelChris SchulzJan KüchlerNiklas GebauerVolker TronnierJan Leppert

Published in: British journal of neurosurgery (2021)

Although this study was performed on a small number of highly selected patients, it demonstrates a synergistic effect of HCQ+BEV in the treatment of rGBM which previously could be demonstrated based on experimental data. A significant increase of OS in patients who receive aRCT+HCQ+BEV cannot be ruled out and should be further investigated in randomised-controlled-trials.

Keyphrases

end stage renal disease
ejection fraction
newly diagnosed
chronic kidney disease
electronic health record
peritoneal dialysis
big data
machine learning
radiation therapy
patient reported
deep learning
artificial intelligence
atomic force microscopy
high speed
plasmodium falciparum