Macrophage Rac2 Is Required to Reduce the Severity of Cigarette Smoke-induced Pneumonia.
Jennifer L Larson-CaseyLinlin GuPatricia L JacksonDavid E BrilesJoanetha Y HaleJ Edwin BlalockJ Michael WellsJessy S DeshaneYong WangDana DavisVeena B AntonyAdriana V F MassicanoSuzanne E LapiA Brent CarterPublished in: American journal of respiratory and critical care medicine (2019)
These observations suggest that therapies to maintain Rac2 activity in lung macrophages restore host defense against respiratory pathogens and diminish the prevalence of LRTIs in subjects that smoke.