Copper-catalyzed enantioselective alkene carboetherification for the synthesis of saturated six-membered cyclic ethers.

Ilyas A BerhaneAmeya S BurdeJonathan J Kennedy-EllisEva Zurek Sherry R Chemler

Published in: Chemical communications (Cambridge, England) (2021)

The enantioselective copper-catalyzed oxidative coupling of alkenols with styrenes for the construction of dihydropyrans, isochromans, pyrans and morpholines is reported. A concise formal synthesis of a σ1 receptor ligand using this alkene carboetherification methodology was demonstrated. Ligand, solvent and base all impact reaction efficiency. DFT transition state calculations are presented.

Keyphrases

density functional theory
molecular dynamics
molecular dynamics simulations
molecular docking
electron transfer
crystal structure
high density
solar cells