Modulation of factor VIII pharmacokinetics by genetic components in factor VIII receptors.
Barbara LunghiMassimo MorfiniNicola MartinelliAlessio BranchiniSilvia LinariGiancarlo CastamanFrancesco BernardiPublished in: Haemophilia : the official journal of the World Federation of Hemophilia (2022)
With the limitation of the small number of HA patients, these observations highlight multiple genetic components acting in distinct phases of FVIII PK and contributing to explain FVIII PK variability. This analysis provides candidates for genotype-based, individual tailoring of FVIII substitutive treatment.