Therapeutic Targeting Potential of Novel Silver Nanoparticles Coated with Anti-CD20 Antibody against Chronic Lymphocytic Leukemia.

Francesco Maria AdamoEstevao Carlos Silva BarcelosFilomena De FalcoErica DorilloChiara RompiettiDaniele SorciniArianna StellaBeatrice Del PapaStefano BaldoniAngela EspositoClelia GeraciRoberta ArcaleniChiara PennettaFrancesco RagoneseLorenzo MorettiMariagrazia MameliMauro Di IanniEmanuela RosatiBernard FiorettiPaolo Sportoletti

Published in: Cancers (2023)

AgNPs showed strong anti-leukemic activity in CLL, with the potential for clinical translation in combination with agents used in CLL. The increased specificity of AgNPs@Rituximab toward CLL cells could be relevant for overcoming in vivo AgNPs' non-specific distribution and increasing their efficacy.

Keyphrases

chronic lymphocytic leukemia
silver nanoparticles
induced apoptosis
acute myeloid leukemia
signaling pathway
oxidative stress
climate change
risk assessment
drug delivery
diffuse large b cell lymphoma
structural basis