Single-nucleotide polymorphism rs2070600 regulates AGER splicing and the sputum levels of the COPD biomarker soluble receptor for advanced glycation end-products.

Alen FaizSenani N H RathnayakeNick H T Ten HackenVictor GuryevMaarten van den BergeSimon D Pouwels

Published in: ERJ open research (2021)

The COPD susceptibility SNP rs2070600 affects the levels of the COPD biomarker sRAGE in sputum as well as splicing of AGER. Moreover, @PouwelsScience et al. demonstrate large differences in sRAGE levels between serum and sputum. https://bit.ly/3t0pJtK.

Keyphrases

cystic fibrosis
chronic obstructive pulmonary disease
lung function
mycobacterium tuberculosis
pulmonary tuberculosis
gene expression
binding protein