Effects of sex hormones on vascular reactivity in boys with hypospadias.
Angela K Lucas-HeraldAugusto C MontezanoRheure Alves-LopesLaura HaddowStuart O'TooleMartyn FlettBoma LeeS Basith AmjadMairi StevenJane McNeillyKatriona BrooksbankRhian M TouyzSyed Faisal AhmedPublished in: The Journal of clinical endocrinology and metabolism (2023)
In healthy boys, testosterone and 17β-estradiol promote a vasoconstrictor phenotype whereas in boys with hypospadias, these sex hormones reduce vasoconstriction, with androgens promoting vasorelaxation. Differences in baseline artery function may therefore be sex hormone independent and the impact of early-life variations in androgen exposure on vascular function needs further study.