Mechanistic investigation of synergistic interaction of tocopherol succinate with a quinoline-based inhibitor of mammalian target of rapamycin.

Chittaranjan BeheraJaspreet KourNagma BanjarePraveen K VermaGousia ChashooSanghapal D SawantPrem N Gupta

Published in: The Journal of pharmacy and pharmacology (2021)

The investigated combination synergistically inhibited proliferation of MIA PaCa-2 cells through simultaneous induction of autophagy followed by apoptosis, and this combination demonstrated potential for further translational studies.

Keyphrases

cell cycle arrest
induced apoptosis
endoplasmic reticulum stress
cell death
signaling pathway
oxidative stress
pi k akt
cancer therapy
atomic force microscopy
human health
risk assessment
high speed