Irisin improves delayed bone repair in diabetic female mice.

Yuko KinoshitaYoshimasa TakafujiKatsumi OkumotoYuto TakadaHiroki EharaYuya MizukamiNaoyuki KawaoJun-Ichiro JoYasuhiko TabataHiroshi Kaji

Published in: Journal of bone and mineral metabolism (2022)

We first showed that local irisin administration with gelatin hydrogel sheets improves the delayed bone repair induced by diabetic state partially by enhancing osteoblastic differentiation.

Keyphrases

wound healing
bone regeneration
bone mineral density
type diabetes
hyaluronic acid
bone loss
drug delivery
tissue engineering
high fat diet induced
postmenopausal women
vascular smooth muscle cells
insulin resistance
angiotensin ii
wild type