Canonical Thyroid Hormone Receptor β Action Stimulates Hepatocyte Proliferation in Male Mice.

Georg Sebastian HönesHelena KerpChristoph HoppeManuela KowalczykDenise ZwanzigerHideo Andreas BabaDagmar FührerLars Christian Moeller

Published in: Endocrinology (2022)

Instead of directly activating Wnt signaling, T3 and TRβ induce key genes of the Wnt/β-catenin pathway, ultimately stimulating hepatocyte proliferation via CyclinD1. Thus, canonical transcriptional TRβ action is necessary for T3-mediated stimulation of hepatocyte proliferation.

Keyphrases

signaling pathway
liver injury
stem cells
gene expression
cell proliferation
drug induced
transcription factor
heat shock
genome wide identification