NMR Relaxometry to Characterize the Drug Structural Phase in a Porous Construct.

Linn W ThraneEmily A BerglundJames N WilkingDavid VodakJoseph D Seymour

Published in: Molecular pharmaceutics (2018)

Nuclear magnetic resonance (NMR) frequency spectra and T2 relaxation time measurements, using a high-power radio frequency probe, are shown to characterize the presence of an amorphous drug in a porous silica construct. The results indicate the ability of non-solid-state NMR methods to characterize crystalline and amorphous solid structural phases in drugs. Two-dimensional T1- T2 magnetic relaxation time correlation experiments are shown to monitor the impact of relative humidity on the drug in a porous silica tablet.

Keyphrases

solid state
magnetic resonance
drug induced
metal organic framework
adverse drug
single molecule
room temperature
highly efficient
high resolution
magnetic resonance imaging
contrast enhanced
living cells
density functional theory