Tau pathology and relative cerebral blood flow are independently associated with cognition in Alzheimer's disease.
Denise VisserEmma E WoltersSander C J VerfaillieEmma M CoomansTessa TimmersHayel TuncelJuhan ReimandRonald BoellaardAlbert D WindhorstPhilip ScheltensWiesje M van der FlierRik OssenkoppeleBart N M van BerckelPublished in: European journal of nuclear medicine and molecular imaging (2020)
Tau pathology was associated with locally reduced rCBF. Tau pathology and low rCBF were both independently associated with worse cognitive performance. For tau pathology, these associations spanned widespread neocortex, while for rCBF, independent associations were restricted to lateral temporal and parietal regions and the executive functioning and attention domains. These findings indicate that each biomarker may independently contribute to cognitive impairment in AD.