Management of Stroke in Patients With Chronic Liver Disease: A Practical Review.
Neal S ParikhElora BasuMu Ji HwangRussel RosenblattLisa B Van WagnerHana I LimSantosh B MurthyHooman KamelPublished in: Stroke (2023)
Chronic liver disease (CLD) is a highly prevalent condition. There is burgeoning recognition that there are many people with subclinical liver disease that may nonetheless be clinically significant. CLD has a variety of systemic aberrations relevant to stroke, including thrombocytopenia, coagulopathy, elevated liver enzymes, and altered drug metabolism. There is a growing body of literature on the intersection of CLD and stroke. Despite this, there have been few efforts to synthesize these data, and stroke guidelines provide scant guidance on this topic. To fill this gap, this multidisciplinary review provides a contemporary overview of CLD for the vascular neurologist while appraising data regarding the impact of CLD on stroke risk, mechanisms, and outcomes. Finally, the review addresses acute and chronic treatment considerations for patients with stroke-ischemic and hemorrhagic-and CLD.
Keyphrases
- atrial fibrillation
- cerebral ischemia
- systematic review
- emergency department
- drug induced
- metabolic syndrome
- electronic health record
- big data
- gene expression
- adipose tissue
- intensive care unit
- machine learning
- weight loss
- dna methylation
- subarachnoid hemorrhage
- adverse drug
- acute respiratory distress syndrome
- genome wide
- data analysis
- mechanical ventilation