Lactylation-Related Gene Signature Effectively Predicts Prognosis and Treatment Responsiveness in Hepatocellular Carcinoma.

Zhe ChengHuichao HuangMaoyu LiXujun LiangYuying TanYongheng Chen

Published in: Pharmaceuticals (Basel, Switzerland) (2023)

The lactylation-related model exhibited robust predictive efficiency in HCC. The glycolysis pathway was enriched in the HCC tumor samples. A low-risk score indicated better treatment response to most targeted drugs and immunotherapy. The lactylation-related gene signature could be used as a biomarker for the effective clinical treatment of HCC.

Keyphrases

genome wide
copy number
transcription factor
drug delivery
dna methylation
replacement therapy