Repurposing dimethyl fumarate as an antiepileptogenic and disease-modifying treatment for drug-resistant epilepsy.

Sereen SandoukaPrince Kumar SinghAseel SaadiRhoda Olowe TaiwoYara SheeniTaige ZhangLarin DeebMichelle GuignetSteve H WhiteTawfeeq Shekh-Ahmad

Published in: Journal of translational medicine (2023)

Taken together, these findings suggest that DMF, through the activation of Nrf2, has the potential to serve as a therapeutic target for preventing epileptogenesis and modifying epilepsy.

Keyphrases

drug resistant
multidrug resistant
acinetobacter baumannii
temporal lobe epilepsy
oxidative stress
cystic fibrosis
human health
risk assessment
smoking cessation