Integrative Bioinformatics Analysis Reveals Potential Target Genes and TNFα Signaling Inhibition by Brazilin in Metastatic Breast Cancer Cells.

Published in: Asian Pacific journal of cancer prevention : APJCP (2020)

In conclusion, this study identified eight PB, including MMP14, PTGS2, ADAM17, PTEN, CCL2, PIK3CB, MAP3K8, and CXCL3. In addition, brazilin possibly inhibits metastatic breast cancer through inhibition of TNFα signaling. The study results study need to be validated with in vitro and in vivo studies to strengthen scientific evidence of the use of brazilin in breast cancer metastasis inhibition.

Keyphrases

squamous cell carcinoma
bioinformatics analysis
cell proliferation
risk assessment
gene expression
heavy metals
dna methylation
climate change
signaling pathway
pi k akt