Role of computational and structural biology in the development of small-molecule modulators of the spliceosome.
Riccardo RozzaPavel JanošAngelo SpinelloAlessandra MagistratoPublished in: Expert opinion on drug discovery (2022)
This review highlights the potential of modulating pre-RNA splicing with small-molecules, and anticipates how the synergy of computer and wet-lab experiments will enrich our understanding of splicing regulation/deregulation mechanisms. This information will aid future structure-based drug-discovery efforts aimed to expand the currently limited portfolio of selective splicing-modulators.