Sirt1 Deficiency Promotes Age-Related AF Through Enhancing Atrial Necroptosis by Activation of RIPK1 Acetylation.
Xuexin JinYun ZhangYun ZhouYingchun LuoXuejie HanYunlong GaoHui YuYu DuanLing ShiYue YuYue LiPublished in: Circulation. Arrhythmia and electrophysiology (2024)
Our findings first demonstrated that Sirt1 exerts significant efficacy in countering age-related AF by impeding atrial necroptosis through regulation of RIPK1 acetylation, highlighting that the activation of Sirt1 or the inhibition of necroptosis could potentially serve as a therapeutic strategy for age-related AF.