In-silico Prediction of the Beta-carboline Alkaloids Harmine and Harmaline as Potent Drug Candidates for the Treatment of Parkinson's disease.

Rumpa BanerjeeMukesh KumarIsha GauravSudha ThakurAbhimanyu ThakurKunal SinghSanchari KarakRajeswar DasMohit Chhabra

Published in: Anti-inflammatory & anti-allergy agents in medicinal chemistry (2022)

Harmine and Harmaline exhibit higher binding affinity towards D2- and D3- dopamine receptors compared to L-DOPA, and PKs and toxicity profile support their potential as drug candidates for PD therapy.

Keyphrases

adverse drug
molecular docking
uric acid
drug induced
emergency department
stem cells
human health
risk assessment
transcription factor
replacement therapy
bone marrow
molecular dynamics simulations
smoking cessation