Cardiovascular safety of macrolide and fluoroquinolone antibiotics: An analysis of the WHO database of adverse drug reactions.

Giulia BonaldoLuisa Anna AndrianiOttavio D'AnnibaliDomenico MotolaAlberto Vaccheri

Published in: Pharmacoepidemiology and drug safety (2019)

Our data highlighted that macrolides and fluoroquinolones may influence cardiac rhythm and suggest caution in the prescribing of these drugs to patients with hidden cardiovascular risk factors. Although these ADRs seem to be not common, they have a notable impact in clinical practice because of the huge number of the exposed subjects.

Keyphrases

adverse drug
cardiovascular risk factors
electronic health record
clinical practice
cardiovascular disease
metabolic syndrome
drug induced
emergency department
left ventricular
atrial fibrillation
heart rate
big data
primary care
blood pressure
heart failure
type diabetes