Distinct protein patterns related to postnatal development in small for gestational age preterm infants.
Eva R SmitMichelle RomijnPieter LangerhorstCarmen van der ZwaanHilde van der StaaijJoost RotteveelAnton H van KaamSuzanne F Fustolo-GunninkArie J HoogendijkWes OnlandMartijn J J FinkenMaartje van den BiggelaarPublished in: Pediatric research (2024)
Postnatal changes of circulating proteins in preterm infants have not fully been elucidated but may contribute to development of health complications. Mass spectrometry-based analysis is an attractive approach to study circulating proteins in preterm infants with limited material. Longitudinal plasma profiling reveals postnatal developmental-related patterns in preterm infants (314/833 proteins) including previously described changes, but also previously unreported proteins. Longitudinal monitoring revealed an immune response signature between SGA and AGA infants. This study highlights the importance of taking postnatal changes into account for translational studies in preterm infants.