Clinical grade production of IL-15 stimulated NK cells for early infusion in adult AML patients undergoing haploidentical stem cell transplantation with post-transplant cyclophosphamide.
Eva Rubio-AzpeitiaAna Maria Pérez-CorralNieves Dorado-HerreroSilvia MonsalvoGonzalo Pérez-BalseraMaria Eugenia Fernández-SantosMi KwonGillen OarbeascoaMariana Bastos-OreiroCarmen FaleroCristina Pascual IzquierdoCristina Muñoz-MartínezPérez-Martínez AntonioJosé Luis Diez-MartinJavier AnguitaPublished in: Transfusion (2022)
Our results demonstrate the safety and feasibility of manufactured NK IL15 cells obtained from an adult allogeneic donor in the setting of haploidentical transplantation for AML patients.
Keyphrases
- stem cell transplantation
- high dose
- nk cells
- low dose
- patients undergoing
- acute myeloid leukemia
- end stage renal disease
- ejection fraction
- induced apoptosis
- chronic kidney disease
- newly diagnosed
- peritoneal dialysis
- bone marrow
- allogeneic hematopoietic stem cell transplantation
- stem cells
- oxidative stress
- cell therapy
- cell death
- pi k akt
- patient reported