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Hepatic stellate cells activate and avoid death under necroptosis stimuli: Hepatic fibrosis during necroptosis.

Ju Hee OhWaqar Khalid SaeedHye Young KimSeung Min LeeA Hyeon LeeGye Ryeol ParkEileen L YoonDae Won Jun
Published in: Journal of gastroenterology and hepatology (2023)
HSCs avoid necroptosis due to the absence of MLKL phosphorylation and oligomerization and are activated through autophagosome and NF-κB pathways.
Keyphrases
  • induced apoptosis
  • signaling pathway
  • cell cycle arrest
  • oxidative stress
  • pi k akt
  • lps induced
  • cell death
  • endoplasmic reticulum stress
  • inflammatory response
  • immune response
  • toll like receptor